Invitrogen™ CD300b Monoclonal Antibody (339003)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524069

Catalog No. PIMA524069

Description

In direct ELISAs, 100% cross-reactivity with recombinant human (rh) LMIR5 is observed and no cross-reactivity with recombinant mouse (rm) LMIR3, rmLMIR4, rhLMIR1, rhLMIR2, or rhLMIR6 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

CD300 molecule-like family member b (CD300LB), also known as CLM-7, is a gene located on chromosome 17q25.1, encoding an immunoreceptor that belongs to the CD300 family of molecules. CD300LB is primarily expressed on the surface of myeloid cells, including dendritic cells and macrophages, where it plays an essential role in modulating immune responses. The receptor is involved in the regulation of cell activation and inflammatory responses through its interactions with phosphatidylserine and other lipid ligands, which can lead to either activation or inhibition of immune cell functions. CD300LB influences processes like antigen presentation, phagocytosis, and cytokine production, thereby impacting innate immune responses and the maintenance of immune homeostasis. Its expression and activity are of particular interest in contexts like autoimmunity, infection, and cancer, where it may contribute to disease progression and serve as a potential therapeutic target in modulating immune functions.

Specifications

• Antigen: CD300b
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q3U497
• Gene Symbols: CD300LB
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse CD300b/LMIR5 Ile18-Tyr157.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 339003
• Conjugate: Unconjugated
• Gene: CD300LB
• Gene Alias: CD300 antigen like family member B; CD300 antigen-like family member B; CD300 molecule like family member b; CD300 molecule-like family member b; CD300b; CD300LB; CLM7; CLM-7; CMRF35A2; CMRF35-A2; CMRF35-like molecule 7; CMRF-35-like molecule-7; Gm253; Immune receptor expressed on myeloid cells 3; IREM3; IREM-3; Leukocyte mono-Ig-like receptor 5; LMIR5; TREM5; TREM-5; triggering receptor expressed on myeloid cells 5; UNQ2530/PRO6029
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 217304
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized