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CD300e (IREM-2) Mouse anti-Human, PE, Clone: UP-H2, eBioscience™

Mouse Monoclonal Antibody

$186.00 - $341.00

Specifications

Antigen CD300e (IREM-2)
Clone UP-H2
Target Species Human
Conjugate PE
Isotype IgG1
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-107-45
Encompass
View Documents
Invitrogen
12300742
100 Tests
Each for $341.00
Add to cart
 
50-107-44
Encompass
View Documents
Invitrogen
12300741
25 Tests
Each for $186.00
Add to cart
 
Description

Description

Description: The monoclonal antibody UP-H2 recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34 kDa Ig-like containing receptor is an activating receptor and through it′s charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC′s. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2. In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes. Applications Reported: This UP-H2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This UP-H2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered.

CD300e is a member of the glycoprotein family of cell surface proteins expressed on myeloid cells. CD300e interacts with the TYRO protein tyrosine kinase-binding protein and is thought to be involved as an activating receptor. CD300e is expressed on mature myeloid dendritic cells and monocytes, and is down regulated on immature dendritic cells. Further, CD300e interacts with DAP-12, which mediates activating signals. The alloreactive response of naïve T cells has been reported to become enhanced by the activation of CD300e. Diseases associated with CD300e dysfunction include tungiasis and lice infestation.
Specifications

Specifications

CD300e (IREM-2)
Human
IgG1
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO
UP-H2
PE
Flow Cytometry
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
SDS
Product Certifications

For Research Use Only.

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