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Invitrogen™ CD300f (IREM-1) Monoclonal Antibody (UP-D1), eFluor™ 660, eBioscience™
Mouse Monoclonal Antibody
Supplier: Invitrogen™ 50300842

Description
Description: The monoclonal antibody recognizes human IREM-1 (Immune receptor expressed by myeloid cell 1). IREM-1 is also a member of of the CD300 family specifically referred to as CD300f. IREM-1 is a type I transmembrane protein with a single Ig domain, one predicted N-linked glycosylation site and a long cytoplasmic tail which contains a predicted ITIM domain categorizing it as an inhibitory receptor. Additionally the cytoplasmic domain has been shown to interact with SHP-1 and the p85\alpha subunit of PI3K. Expression is restricted to myeloid cells. In peripheral blood IREM-1 is found on monocytes and granulocytes. In monocyte derived dendritic cells, expression of IREM-1 is downregulated. Applications Reported: This UP-D1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This UP-D1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 μm p...
CLM1 is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP.
Specifications
CD300f (IREM-1) | |
Monoclonal | |
5 μL/Test | |
PBS with BSA and 0.09% sodium azide; pH 7.2 | |
Q8TDQ1 | |
CD300LF | |
Affinity chromatography | |
RUO | |
146722 | |
4°C, store in dark, DO NOT FREEZE! | |
Liquid |
Flow Cytometry | |
UP-D1 | |
eFluor 660 | |
CD300LF | |
CD300 antigen like family member F; CD300 antigen-like family member F; CD300 molecule like family member f; CD300 molecule-like family member f; CD300f; Cd300lf; CLIM1; CLM1; CLM-1; CMRF-35-like molecule 1; CMRF35-like molecule 1; DC-derived Ig-like receptor 2; Digr2; F730004D16Rik; IgSF13; Immune receptor expressed on myeloid cells 1; immunoglobin superfamily member 13; immunoglobulin superfamily member 13; inhibitory receptor IREM1; IREM1; IREM-1; Leukocyte mono-Ig-like receptor 3; Lmir3; MAIR-5; MAIR-V; myeloid-associated immunoglobulin-like receptor 5; NK inhibitory receptor; NKIR; Pigr3; UNQ3105/PRO10111 | |
Mouse | |
100 Tests | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
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