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  6. Invitrogen™ CD301b (MGL2) Monoclonal Antibody (11A10-B7), eBioscience™, Invitrogen™ 

Invitrogen™ CD301b (MGL2) Monoclonal Antibody (11A10-B7), eBioscience™, Invitrogen™

Catalog No. 14301137
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2 mg
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14-301-137 2 mg
14-301-182 100 μg
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Catalog No. 14-301-137 Supplier Invitrogen™ Supplier No. 14301137
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Description

Rat Monoclonal Antibody

Description: The monoclonal antibody 11A10-B7 recognizes mouse CD301b. CD301b is also known as macrophage galactose-type C-type lectin 2 (MGL2). CD301b expression is restricted to dermal dendritic cells, connection tissue, and bone marrow derived dendritic cells. Macrophages also express CD301b at low levels. CD301b contains a single carbohydrate recognition domain that recognizes protein antigens that have a galactose and N-acetylgalactosamine (Gal/GalNAc). Gal/GalNAc protein antigens are efficiently internalized through CD301b and presented to antigen specific CD4+ cells via MHC Class II. CD301b+ dendritic cells are believed to play an important role in TH2 priming. Applications Reported: This 11A10-B7 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, and microscopy. Applications Tested: This 11A10-B7 antibody has been tested by immunohistochemistry of frozen mouse tissue and can be used at less than or equal to 10 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered.

CD301b is also known as macrophage galactose-type C-type lectin 2 (MGL2). CD301b expression is restricted to dermal dendritic cells, connection tissue, and bone marrow derived dendritic cells. Macrophages also express CD301b at low levels. CD301b contains a single carbohydrate recognition domain that recognizes protein antigens that have a galactose and N-acetylgalactosamine (Gal/GalNAc). Gal/GalNAc protein antigens are efficiently internalized through CD301b and presented to antigen specific CD4+ cells via MHC Class II. CD301b+ dendritic cells are believed to play an important role in TH2 priming.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD301b (MGL2)
Applications Immunohistochemistry (Frozen), Immunocytochemistry
Classification Monoclonal
Clone 11A10-B7
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Mgl2
Gene Accession No. 0
Gene Alias CD301; CD301b; macrophage galactose N-acetyl-galactosamine specific lectin 2; macrophage galactose-type C-type lectin 2; Mgl2
Gene Symbols Mgl2
Host Species Rat
Purification Method Affinity chromatography
Quantity 2 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216864
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a λ
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