CD307a (FCRL1) Mouse, anti-Human, R718, Clone: E3, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752120

Catalog No. BDB752120

Description

The E3 monoclonal antibody specifically recognizes CD307a which is also known as Fc receptor-like protein 1 (FCRL1), Fc receptor homolog 1 (FCRH1), or Immune receptor translocation-associated protein 5 (IRTA5). CD307a (FCRL1) is a type I transmembrane glycoprotein that belongs to the IRTA gene family within the Ig gene superfamily. It has three extracellular Ig-like domains, a glutamic acid residue in its transmembrane region, and two consensus immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain. CD307a (FCRL1) bears sequence homology to classical Fc receptors. CD307a (FCRL1) is first expressed on pre-B cells and increases with maturation being expressed on naïve and memory B cells. It is downregulated by activated germinal center (GC) B cells. It may also be expressed by B cell-derived leukemia and lymphoma cells. CD307a may play key roles in B cell activation, differentiation and effector functions.

Specifications

• Antigen: CD307a (FCRL1)
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: E3
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Form: Liquid