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CD31 (PECAM-1) Monoclonal Antibody (390), PE-eFluor™ 610, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
$376.00
Specifications
| Antigen | CD31 (PECAM-1) |
|---|---|
| Clone | 390 |
| Concentration | 0.2 mg/mL |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
61-031-182
|
Invitrogen™
61031182 |
100 μg |
Each of 1 for $376.00
|
|
|||||
Description
The 390 MAb reacts with mouse CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on all leukocytes and platelets. It has been reported that CD38 binds to CD31. Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction.
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.Specifications
| CD31 (PECAM-1) | |
| 0.2 mg/mL | |
| Monoclonal | |
| Liquid | |
| RUO | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| 18613 | |
| Primary | |
| 4°C, store in dark, DO NOT FREEZE! | |
| Pecam1 |
| 390 | |
| Flow Cytometry | |
| PE-eFluor 610 | |
| Rat | |
| Mouse | |
| Q08481 | |
| IgG2a κ | |
| Affinity Chromatography | |
| Antibody |
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