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Invitrogen™ CD31 Recombinant Rabbit Monoclonal Antibody (RM247)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA533063
Description
Specificity: reacts to human CD31 (Platelet endothelial cell adhesion molecule, PECAM-1). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
Specifications
CD31 | |
Recombinant Monoclonal | |
0.05 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide | |
P16284 | |
Pecam1 | |
A peptide corresponding to the cytoplasmic domain of human CD31 (aa 1-100). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
RM247 | |
Unconjugated | |
Pecam1 | |
C85791; CD31; CD31 antigen; CD31, PECAM-1; CD31/EndoCAM; endoCAM; GPIIA'; I79_008304; PECA1; Pecam; PECAM1; Pecam-1; platelet and endothelial cell adhesion molecule 1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule (CD31 antigen); platelet/endothelial cell adhesion molecule 1; type I transmembrane endothelial adhesion molecule | |
Rabbit | |
Protein A | |
RUO | |
5175 | |
-20°C | |
Liquid |
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