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CD321 (JAM-1) Mouse anti-Human, Brilliant Violet 510, Clone: M.Ab.F11, BD Optibuild™

Catalog No. BDB744064 Shop All BD Biosciences Products
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BDB744064 50 μg
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Catalog No. BDB744064 Supplier BD Biosciences Supplier No. 744064
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Description

Mouse Monoclonal Antibody

The M.Ab.F11 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a 32-35 kDa type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 is expressed on platelets, leucocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and epithelial cells. M.Ab.F11 is a stimulatory antibody that can induce morphological changes, granule secretion, and aggregation in human platelets.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD321 (JAM-1)
Classification Monoclonal
Clone M.Ab.F11
Concentration 0.2mg/mL
Conjugate Brilliant Violet 510
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias JAM-1, Platelet F11 receptor, F11R, JAM-A, PAM-1
Host Species Mouse
Immunogen Human Platelet Membranes
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1 κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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