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  6. Invitrogen™ CD324 (E-Cadherin) Recombinant Rabbit Monoclonal Antibody (BLR088G)

Invitrogen™ CD324 (E-Cadherin) Recombinant Rabbit Monoclonal Antibody (BLR088G)
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Catalog No. PIMA544367
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100 μL
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PIMA544368 10 μL
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Catalog No. PIMA544367 Supplier Invitrogen™ Supplier No. MA544367
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.
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Specifications

Antigen CD324 (E-Cadherin)
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR088G
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene CDH1
Gene Accession No. P12830
Gene Alias AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin
Gene Symbols CDH1
Host Species Rabbit
Immunogen A recombinant protein representing the extracellular domain of human ECadherin (residues 155-707, NP_004351.1).
Purification Method purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 999
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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