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CD328 (Siglec7) Monoclonal Antibody (5-386), FITC, Invitrogen™

Catalog No. PIMA528198
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PIMA528198 100μg
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Catalog No. PIMA528198 Supplier Thermo Scientific Supplier No. MA528198

Description

Mouse Monoclonal Antibody

Mouse anti Human CDw328 antibody, clone 5-386 recognizes human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase.

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD328 (Siglec7)
Applications Flow Cytometry
Classification Monoclonal
Clone 5-386
Concentration 0.1 mg/mL
Conjugate FITC
Formulation PBS with 1% BSA and 0.09% sodium azide
Gene SIGLEC7
Gene Accession No. Q9Y286
Gene Alias Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; SIGLEC-7; SIGLECP2
Gene Symbols SIGLEC7
Host Species Mouse
Immunogen Monocyte-derived dendritic cells
Purification Method Protein G
Quantity 100μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27036
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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