CD328 (Siglec7) Monoclonal Antibody (5-386), FITC, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA528198

Catalog No. PIMA528198

Description

Mouse anti Human CDw328 antibody, clone 5-386 recognizes human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase.

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).

Specifications

• Antigen: CD328 (Siglec7)
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 1% BSA and 0.09% sodium azide
• Gene Accession No.: Q9Y286
• Gene Symbols: SIGLEC7
• Immunogen: Monocyte-derived dendritic cells
• Quantity: 100μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: 5-386
• Conjugate: FITC
• Gene: SIGLEC7
• Gene Alias: Adhesion inhibitory receptor molecule 1; adhesion inhibitory receptor molecule 1, siglec-7; AIRM1; AIRM-1; CD328; CDw328; D-siglec; p75; p75/ AIRM-1; p75/AIRM1; QA79; QA79 membrane protein; sialic acid binding Ig like lectin 7; sialic acid binding Ig-like lectin 7; sialic acid binding immunoglobulin-like lectin 7; sialic acid-binding Ig-like lectin 7; Siglec; SIGLEC19P; SIGLEC7; SIGLEC-7; SIGLECP2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 27036
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
• Form: Liquid

Safety and Handling

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