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Invitrogen™ CD335 (NKp46) Polyclonal Antibody
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Catalog No. PIPA589869
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100 μL
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PIPA589869 100 μL
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Catalog No. PIPA589869 Supplier Invitrogen™ Supplier No. PA589869
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRC FGSYNNHAWS FPSEPVKLLV TGDIENTSLA PEDPTFPDTW GTYLLTTETG LQKDHALWDH TAQNLLRMGL AFLVLVALVW FLVEDWLSRK RTRERASRAS TWEGRRRLNT QTL; Positive Samples: A-549, Mouse spleen, Mouse thymus, Rat spleen, Rat lung; Cellular Location: Cell membrane, Single-pass type I membrane protein.

CD335, also known as NKp46 or NCR1, is a member of the natural cytotoxicity receptor family, which includes NKp30 and NKp44. This type I transmembrane glycoprotein is expressed on NK cells and plays a crucial role in activating and expanding resting NK cells through interactions with dendritic cells. CD335 enhances the ability of NK cells to eliminate tumor and virus-infected cells, such as those infected by influenza. CD335 consists of two Ig-like domains and is related to leukocyte immunoglobulin-like receptors (LIR) and killer inhibitory receptors (KIR). It contributes to the increased efficiency of activated NK cells in mediating tumor cell lysis. Additionally, CD335 interacts with pancreatic beta cells during the development of type 1 diabetes, highlighting its involvement in both immune defense and autoimmune processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD335 (NKp46)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.41 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene NCR1
Gene Accession No. O76036, Q8C567, Q9Z0H5
Gene Alias 1-Mar; activating receptor 1; Ar1; CD335; hNKp46; Kilr1; KILR-1; LY94; Ly-94; lymphocyte antigen 94; Lymphocyte antigen 94 homolog; lymphocyte antigen 94 homolog (activating NK-receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); mAR-1; MAR1 (mouse activating receptor 1); mNKp46; natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; natural killer cell receptor; Ncr1; NK cell-activating receptor; NK receptor KILR-1; NKACTR; Nkp46; NK-p46; NK-p46); rAR-1; rat-activating receptor 1
Gene Symbols NCR1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_0011389292).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117547, 17086, 9437
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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