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  6. Invitrogen™ CD339 (Jagged 1) Monoclonal Antibody (HMJ1-29), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD339 (Jagged 1) Monoclonal Antibody (HMJ1-29), Functional Grade, eBioscience™, Invitrogen™

Catalog No. 163391025
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16-339-1025 25 mg
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Catalog No. 16-339-1025 Supplier Invitrogen™ Supplier No. 163391025
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Description

Armenian Hamster Monoclonal Antibody

Description: This HMJ1-29 monoclonal antibody reacts with mouse Jagged-1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Jagged-1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-1 is expressed by thymic lymphoid and stromal cells, as well as macrophages and CD8+CD11c+ dendritic cells in the spleen. The HMJ1-29 antibody is reported to crossreact to rat. Applications Reported: This HMD1-5 antibody has been reported for use in functional assays. Applications Tested: This HMJ1-29 antibody has been tested by flow cytometric analysis of Jagged-1-transfected CHO cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC.

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD339 (Jagged 1)
Applications Functional Assay
Classification Monoclonal
Clone HMJ1-29
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene JAG1
Gene Accession No. Q63722, Q9QXX0
Gene Alias ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; jagged 1; jagged canonical Notch ligand 1; Jagged1; JAGL1; Ozz; protein jagged-1; Ser-1; Serrate-1
Gene Symbols JAG1
Host Species Armenian Hamster
Purification Method Affinity chromatography
Quantity 25 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16449, 29146
Target Species Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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