CD34 Mouse anti-Human, Rat, Alexa Fluor 350, Clone: ICO-115, Novus Biologicals
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP233076AF350
DescriptionCD34 Monoclonal antibody specifically detects CD34 in Human,Rat samples. It is validated for Western Blot,Flow Cytometry,Immunohistochemistry,Immunocytochemistry,Immunofluorescence,Immunohistochemistry (Paraffin),Immunohistochemistry (Frozen).
|Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen|
|CD34 antigenhematopoietic progenitor cell antigen CD34, CD34 molecule|
|Store at 4°C in the dark.|
|This antibody recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi′s sarcoma, but shows low specificity.|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|Alexa Fluor™ 350|
|50 mM sodium borate with 0.05% sodium azide|
|Blast cells from a chronic myeloid leukemia patient were used as the immunogen for the CD34 antibody.|
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