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  6. Invitrogen™ CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Functional Grade, eBioscience™, Invitrogen™ 

Invitrogen™ CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), Functional Grade, eBioscience™, Invitrogen™

Catalog No. 16587438
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16-587-438 5 mg
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Catalog No. 16-587-438 Supplier Invitrogen™ Supplier No. 16587438
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Description

Rat Monoclonal Antibody

The DTA-1 MAb reacts with mouse GITR, Glucocorticoid-Induced TNFR family gene, also known as TNFRSF18. In naive mice, GITR is expressed predominantly by CD4+CD25+ T regulatory cells (Treg) and by CD25+ CD4+ CD8- thymocytes. Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression. Although it does not deplete CD357 expressing cells in vivo, it has been shown to induce tumorogenesis. The removal of GITR-expressing Treg cells or the administration of DTA-1 resulted in organ specific autoimmune disease.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD357 (AITR/GITR)
Applications Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone DTA-1
Concentration 1 mg/mL
Conjugate Functional Grade
Formulation PBS with no preservative; pH 7.2
Gene Tnfrsf18
Gene Accession No. O35714
Gene Alias Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
Gene Symbols Tnfrsf18
Host Species Rat
Purification Method Affinity chromatography
Quantity 5 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21936
Target Species Mouse
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov
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