Invitrogen™ CD357 (AITR/GITR) Monoclonal Antibody (YGITR765.4.16), PE

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA517934

Catalog No. PIMA517934

Description

MA5-17934 targets GITR in FACS applications and shows reactivity with Mouse samples. The MA5-17934 immunogen is mouse GITR transfectant.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Specifications

• Antigen: CD357 (AITR/GITR)
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: O35714
• Gene Symbols: Tnfrsf18
• Immunogen: Mouse GITR transfectant.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry
• Clone: YGITR765.4.16
• Conjugate: PE
• Gene: Tnfrsf18
• Gene Alias: Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 21936
• Content And Storage: 4°C, do not freeze
• Form: Liquid