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Invitrogen™ CD357 (AITR/GITR) Polyclonal Antibody
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Catalog No. PIPA547883
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100 μg
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PIPA547883 100 μg
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Catalog No. PIPA547883 Supplier Invitrogen™ Supplier No. PA547883
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Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse GITR and recombiant human 4-1BB is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD357 (AITR/GITR)
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Tnfrsf18
Gene Accession No. Q9Y5U5
Gene Alias Activation-inducible TNFR family receptor; AITR; CD357; GITR; GITR-D; glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; TNF receptor superfamily member 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18; tumor necrosis factor receptor superfamily, member 18; UNQ319; UNQ319/PRO364
Gene Symbols Tnfrsf18
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18 Gln26-Glu161 (Thr45Ala).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8784
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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