CD36 Antibody (185-1G2), Alexa Fluor™ 405, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP295271AF405

Catalog No. NB024691

Description

CD36 Monoclonal specifically detects CD36 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Specifications

• Antigen: CD36/SR-B3
• Classification: Monoclonal
• Conjugate: Alexa Fluor 405
• Gene Alias: CD36 antigen, CD36 molecule (thrombospondin receptor), FA6-152, FATCHDS7, Fatty acid translocase, Glycoprotein IIIb, GP3Bthrombospondin receptor), GPIIIB, Leukocyte differentiation antigen CD36, PAS IV, PAS-4, Platelet collagen receptor, platelet glycoprotein 4, Platelet glycoprotein IV, scavenger receptor class B, member 3, Thrombospondin receptor
• Immunogen: Stimulated human leukocytes
• Quantity: 0.1 mL
• Research Discipline: Cancer, Cellular Markers, Endothelial Cell Markers, Hematopoietic Stem Cell Markers, Immunology, Lipid and Metabolism, Stem Cell Markers
• Gene ID (Entrez): 948
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunofluorescence
• Clone: 185-1G2
• Formulation: 50mM Sodium Borate
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Recognizes a protein of 80kDa-90kDa, identified as CD36 (Workshop IV; Code P-26). Its epitope maps between aa155-183. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36. This monoclonal antibody blocks adhesion of P. falciparum parasitized red blood cells to CD36 and strongly inhibits collagen-induced platelet aggregation.
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG2a κ