Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD365 (TIM1) Monoclonal Antibody (1D12-TIM1), PE, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

$410.00

Specifications

Antigen CD365 (TIM1)
Clone 1D12-TIM1
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
View More Specs

Products 1
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
12-365-942
Encompass_Preferred
View Documents Promotion Details
Invitrogen™
12365942
100 Tests
Each of 1 for $410.00
Only null left
Add to Cart
 
Description

Description

Description: This 1D12-TIM1 monoclonal antibody recognizes human CD365 also known as Tim-1, Kim-1 or Havcr1. This antibody was generated using the immunoglobulin V domain of the extracellular part of the CD365 receptor, and is predicted to recognize all three haplotypes of human CD365. Clone 1D12-TIM1 has been shown to block entry of HCV virus into human hepatoma Huh7.5 cells in a dose dependent manner. It has been also shown to block the uptake of apoptotic cells by CD365-expressing 769-P cells. Applications Reported: This 1D12-TIM1 antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1D12-TIM1 antibody has been pre-diluted and tested by flow cytometric analysis of A549 cells. This may be used at 5 μL (0.125 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.
Specifications

Specifications

CD365 (TIM1)
5 μL/Test
Monoclonal
Liquid
RUO
Q96D42
Havcr1
IgG1 κ
Affinity chromatography
Antibody
1D12-TIM1
Flow Cytometry
PE
Mouse
Human
26762
IgV domain of human CD365.
Primary
4°C, store in dark, DO NOT FREEZE!
Havcr1
Videos
SDS
Documents

Documents

Product Certifications
Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.