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CD369 (Clec7a, Dectin-1) Monoclonal Antibody (bg1fpj), PerCP-eFluor™ 710, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  LIFE TECHNOLOGIES 46585982

Encompass_Preferred

Catalog No. 46-585-982

  • $322.65 / Each of 1

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    Reg : $448.00

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Description

Description

The MAb bg1fpj recognizes mouse CD369, also known as Dectin-1 or CLEC7A, a type II transmembrane protein in the C-type lectin family. The ligand is beta1, 3-glycan. Beta glycans are a main component in polysaccharides and specifically beta1,3-linked carbohydrates are found in the cell wall of fungi, plants and some bacteria. CD369 has been found to bind Candida, Aspergillis, Pneumocystis, Coccidioides and Mycobacterium. Calcium dependent binding to ligand signals through syk via the ITAM domain in the cytoplasmic portion and results in endocyotosis/phagocytosis and production of cytokines (IL-2, IL-6, IL-10, TNF alpha, IL-1 beta, IL-23). A direct role in Th17 and Th1 differentiation has been attributed to CD369 signaling. CD369 is expressed predominantly on myeloid cells (neutrophils, monocytes, macrophages, and dendritic cells). Low levels have also been reported on lymphocytes and mucosal epithelium.

CD369 (Clec7a, Dectin-1) Monoclonal antibody specifically detects CD369 (Clec7a, Dectin-1) in Mouse samples. It is validated for Flow Cytometry.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD369 (Clec7a, Dectin-1)
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q6QLQ4
Clec7a
Baculovirus-expressed Fc-containing protein
100 μg
Primary
Mouse
Antibody
IgG2a κ
Flow Cytometry
bg1fpj
PerCP-eFluor 710
Clec7a
Beta-glucan receptor; beta-GR; BGR; CANDF4; CD369; CLEC7A; Clec7b; CLECSF12; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; DC-associated C-type lectin 1; DECTIN1; dectin-1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; RGD1565140; SCARE2; UNQ539/PRO1082
Rat
Affinity chromatography
RUO
56644
4° C, store in dark, DO NOT FREEZE!
Liquid
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