Invitrogen™ CD37 Recombinant Mouse Monoclonal Antibody (MB-1)

Mouse Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA548039

Catalog No. PIMA548039

Description

Specificity: This antibody is specific for human CD37, which is expressed on virtually all mature B lymphocytes, but not on pro-B or plasma cells. CD37 is highly expressed on all forms of B cell non-Hodgkin lymphoma, chronic lymphocyte leukemia, and other leukemias. CD37 does not appear to be expressed on T cells, thymocytes, granulocytes or platelets. Preparation: BALB/c mice were immunized with lymph node cells from a patient with nodular poorly differentiated lymphocytic lymphoma. Immunophenotyping studies of these cells identified them as B cells expressing SIgG/lambda, as well as HLA-DR. Leu-12, and B1.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: CD37
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% ProClin 300
• Gene Accession No.: P11049
• Gene Symbols: CD37
• Immunogen: BALB/c mice were immunized with lymph node cells from a patient with nodular poorly differentiated lymphocytic lymphoma.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: MB-1
• Conjugate: Unconjugated
• Gene: CD37
• Gene Alias: CD37; CD37 antigen; CD37 molecule; cell differentiation antigen 37; GP52-40; Leukocyte antigen CD37; leukocyte surface antigen CD37; tetraspanin-26; Tspan26; Tspan-26
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 951
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid