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Tocris Bioscience™ CD38 inhibitor
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Catalog No. 63915
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63-915 5 mg
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Catalog No. 63-915 Supplier Tocris Bioscience™ Supplier No. 6391/5
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Description

Potent CD38 inhibitor; active in vivo

CD38 inhibitor 78c is a potent CD38 (ADP ribosyl cyclase/hydrolase) inhibitor (IC50 values are 1.9 and 7.3 nM at mouse and human CD38, respectively). Catalyzes breakdown of NAD to nicotinamide and ADPR, and hydrolyzes NAADP to adenosine-5'-O-diphosphoribose phosphate. Elevates NAD+ levels >5-fold in liver and >1.2-fold in muscle of diet-induced obese (DIO) C57Bl6 mice. Also prevents age-related NAD+ decline in mice. Improves glucose intolerance, cardiac function and improves physiological and metabolic parameters in old mice.

Specifications

Chemical Name or Material 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1 H)-quinolinone
CAS 1700637-55-3
Quantity 5 mg
Target Hydrolase Inhibitors
Molecular Formula C22H27N3O3S
Purity 0.98
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