CD38 Mouse anti-Human, Clone: OTI1C9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF804538

Catalog No. 50-166-7026

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, maligt lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter′s Syndrome.

Specifications

• Antigen: CD38
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CD38
• Gene Alias: ADPRC 1, ADPRC1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 952
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1C9
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P28907
• Gene Symbols: CD38
• Immunogen: Human recombit protein fragment corresponding to amino acids 43-300 of human CD38 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1