Invitrogen™ CD3d Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588511

Catalog No. PIPA588511

Description

Immunogen sequence: FKIPIEELED RVFVNCNTSI TWVEGTVGTL LSDITRLDLG KRILDPRGIY RCNGTDIYKD KESTVQVHYR MCQSCVELDP ATVA; Positive Samples: Jurkat; Cellular Location: Membrane, Single-pass type I membrane protein.

CD3d is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The CD3d protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in the CD3d gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms of CD3d have been found. Other variants of CD3d may also exist, but the full-length nature of their transcripts have yet to be defined.

Specifications

• Antigen: CD3d
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cd3d
• Gene Alias: CD3 antigen delta polypeptide; CD3 antigen, delta polypeptide; CD3 antigen, delta subunit; CD3 delta; CD3 molecule delta polypeptide; CD3 molecule, delta; CD3D; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule; CD3d molecule, delta (CD3-TCR complex); CD3-DELTA; IMD19; OKT3, delta chain; T3D; T-cell receptor T3 delta chain; T-cell surface glycoprotein CD3 delta chain
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25710, 915
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.27 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P04234, P19377
• Gene Symbols: Cd3d
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-105 of human CD3D (NP_0007231).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG