CD4 Mouse anti-Human, Alexa Fluor 700, Clone: RPA-T4, BD

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
BDB561030	BD Biosciences 561030	25 μg
BDB557922	BD Biosciences 557922	0.1 mg

Description

The RPA-T4 monoclonal antibody specifically binds to CD4, a 59 kDa single-chain transmembrane glycoprotein that is expressed on T-helper/inducer cell populations. CD4 is also expressed on thymocytes subsets and at lower levels on monocytes and macrophages. CD4 functions as a co-receptor in MHC class II-restricted antigen-induced T cell activation and as a receptor for human immunodeficiency viruses (HIV). This antibody binds to the D1 domain (CDR1 and CDR3 epitopes) of the CD4 antigen and reacts with approximately 80% of thymocytes and 45% of peripheral blood lymphocytes. RPA-T4 is capable of blocking HIV-1, gp120, and inhibits syncytium formation.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

Specifications

• Antigen: CD4
• Concentration: 0.2mg/mL
• Classification: Monoclonal
• Host Species: Mouse
• Target Species: Human
• Isotype: IgG1 κ
• Purification Method: Affinity Purified

• Clone: RPA-T4
• Applications: Flow Cytometry
• Conjugate: Alexa Fluor 700
• Regulatory Status: RUO
• Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

For Research Use Only.