CD4 Mouse anti-Human, RB545, Clone: SK3 (also known as Leu3a), BD Horizon™

Catalog No.	Quantity
BDB569183	100 Tests

Catalog No. BDB569183 Supplier BD Biosciences Supplier No. 569183

Description

Mouse Monoclonal Antibody

The SK3 monoclonal antibody specifically binds to CD4. The CD4 antigen is a 55 kDa type 1 transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed on T-helper/inducer lymphocytes and monocytes. CD3+CD4+ T cells comprise approximately 28% to 58% of normal peripheral blood lymphocytes. CD4 is also expressed on 80% to 95% of normal thymocytes. The CD4 antigen is present in low density on the cell surface of monocytes and in the cytoplasm of monocytes and macrophages (CD3-CD4+). CD4 serves as a T cell coreceptor for MHC class II antigen recognition and as a receptor for the human immunodeficiency virus (HIV). The SK3 antibody inhibits HIV binding to CD4+ cells.

CD4 Monoclonal antibody specifically detects CD4 in Human samples. It is validated for Flow Cytometry

Specifications

• Antigen: CD4
• Applications: Flow Cytometry
• Classification: Monoclonal
• Clone: SK3 (also known as Leu3a)
• Conjugate: RB545
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Gene Alias: L3T4; Leu3a; T-cell surface antigen T4/Leu-3 ; W3/25 ; CD4 antigen (p55)
• Host Species: Mouse
• Immunogen: Human Peripheral Blood T Cells
• Purification Method: Affinity Purified
• Quantity: 100 Tests
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 920
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated to the dye under optimum conditions and unreacted dye was removed.
• Form: Purified
• Isotype: IgG1 κ
• Excitation/Emission: Excitation Source: Blue 488 nm, Excitation Max: 496 nm, Emission Max: 545 nm