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CD4 v4 Mouse anti-Human, Brilliant Violet 510, Clone: L120, BD Optibuild™

Catalog No. BDB742651 Shop All BD Biosciences Products
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BDB742651 50 μg
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Catalog No. BDB742651 Supplier BD Biosciences Supplier No. 742651
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Description

Mouse Monoclonal Antibody

The L120 monoclonal antibody specifically recognizes CD4. CD4 is an ñ59 kDa type I transmembrane glycoprotein that belongs to the Ig gene superfamily. CD4 is expressed on helper-inducer subset of T lymphocytes and monocytes. The CD4 antigen is involved in the Major Histocompatibility Complex (MHC) class II-restricted recognition of foreign antigens and has been identified as a receptor for HIV. The L120 antibody recognizes amino acids 306-370 of the antigen and does not block the binding of the gp120 of HIV, but inhibits the proliferation of CD4 T lymphocytes to MHC class II antigens. The CD4 antigen is present on most thymocytes, approximately 40% of peripheral blood lymphocytes, and at lower density on monocytes. Peripheral blood CD4+ T lymphocytes are lost over time during HIV infection, and this loss is correlated with disease progression.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD4 v4
Classification Monoclonal
Clone L120
Concentration 0.2mg/mL
Conjugate Brilliant Violet 510
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias L3T4, T-cell surface antigen T4/Leu-3, W3/25, CD4 antigen (p55)
Host Species Mouse
Immunogen Human Peripheral Blood Lymphocytes
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG1
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