CD4 v4 Mouse, anti-Human, R718, Clone: L120, BD OptiBuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 752085

Catalog No. BDB752085

Description

The L120 monoclonal antibody specifically recognizes CD4. CD4 is an ∼59 kDa type I transmembrane glycoprotein that belongs to the Ig gene superfamily. CD4 is expressed on helper-inducer subset of T lymphocytes and monocytes. The CD4 antigen is involved in the Major Histocompatibility Complex (MHC) class II-restricted recognition of foreign antigens and has been identified as a receptor for HIV. The L120 antibody recognizes amino acids 306-370 of the antigen and does not block the binding of the gp120 of HIV, but inhibits the proliferation of CD4 T lymphocytes to MHC class II antigens. The CD4 antigen is present on most thymocytes, approximately 40% of peripheral blood lymphocytes, and at lower density on monocytes. Peripheral blood CD4+ T lymphocytes are lost over time during HIV infection, and this loss is correlated with disease progression.

Specifications

• Antigen: CD4 v4
• Classification: Monoclonal
• Conjugate: R718
• Quantity: 50 μg
• Primary or Secondary: Primary
• Content And Storage: Refrigerate Upon Arrival

• Applications: Flow Cytometry
• Clone: L120
• Host Species: Mouse
• Regulatory Status: RUO
• Target Species: Human
• Form: Liquid