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CD40 Mouse anti-Human, Clone: HB14, Abnova™

Catalog No. 89933811 Shop All Abnova Corporation Products
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50 μg
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Catalog No. Quantity
89-933-811 50 μg
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Catalog No. 89-933-811 Supplier Abnova Corporation Supplier No. MAB12953
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Description

Mouse monoclonal antibody raised against human CD40.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]

Specifications

Antigen CD40
Applications Flow Cytometry, Immunohistochemistry (PFA fixed)
Classification Monoclonal
Clone HB14
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against human CD40.
Dilution Flow Cytometry (0.5 ug/106 cells) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS, pH 7.2 (0.09% sodium azide).
Gene Alias Bp50/CDW40/MGC9013/TNFRSF5/p50
Gene Symbols CD40
Host Species Mouse
Immunogen Human B cell line.
Purification Method Affinity purification
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 958
Target Species Human
Content And Storage Store at 4°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1 κ
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