Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. NB016172

CD40/TNFRSF5 Antibody (5D12), DyLight 680, Novus Biologicals™
SDP

Catalog No. NB016172 Shop All R&D Systems Products
Change view
Click to view available options
Quantity:
0.1 mL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
NB016172 0.1 mL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. NB016172 Supplier Novus Biologicals Supplier No. NBP281104FR
Only null left
Add to Cart
Add to Cart

Description

Human Monoclonal Antibody

CD40/TNFRSF5 Monoclonal specifically detects CD40/TNFRSF5 in Human, Cynomolgus Monkey samples. It is validated for Flow Cytometry, ELISA, Immunohistochemistry.

Specifications

Antigen CD40/TNFRSF5
Applications Flow Cytometry, ELISA, Immunohistochemistry
Classification Monoclonal
Clone 5D12
Conjugate DyLight 680
Dilution Flow Cytometry, ELISA, Immunohistochemistry
Formulation 50mM Sodium Borate
Gene Alias B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5
Gene Symbols CD40
Host Species Human
Immunogen Anti-CD40/TNFRSF5 mAb 5D12, was generated by immunizing mice with sf9 insect cells expressing recombinant human CD40/TNFRSF5 and selected for the ability to bind EBV-immortalized human B cells. The variable regions from mu5D12 were cloned and used to construct chimeric humanized IgG4 5D12.
Purification Method Protein A purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Adaptive Immunity, Apoptosis, Asthma, B Cell Development and Differentiation Markers, Cancer, Hematopoietic Stem Cell Markers, Immunology, Signal Transduction, Stem Cell Markers
Primary or Secondary Primary
Gene ID (Entrez) 958
Test Specificity ch5D12 binds specifically to recombinant and native human CD40/TNFRSF5 ectodomain and has been shown to also bind CD40/TNFRSF5 in cynomolgus and marmoset monkeys. The antibody requires residues within D1 and D1/B2 for binding (Hager et al, 2003) (D1 domain is crucial for CD40L binding). Binding characteristics are very similar between humanized ch5D12 and mu5D12. CD40/TNFRSF5 is a glycoprotein of the TNFR superfamily and is expressed on all mature B cells, dendritic cells, activated monocytes, some endothelial cells and some epithelium including the thymus. CD40/TNFRSF5 binds to CD40L, and this interaction is involved in B-cell activation and proliferation, antigen-presenting cell (APC) activation, initiation of antigen-specific T-cell responses, immunoglobulin production, activation of effector macrophages isotype switching, homotypic adhesion and rescue from apoptosis.
Target Species Human, Cynomolgus Monkey
Content And Storage Store at 4°C in the dark.
Form Purified
Isotype IgG4 κ
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.