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CD42b Mouse anti-Human, APC, Clone: MM2/174, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A15459

Catalog No. 50-113-7059


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Description

Description

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Specifications

Specifications

CD42b
Monoclonal
0.1 mg/mL
PBS with 0.1% sodium azide
P07359
BSS, CD42B, CD42b-alpha, GP1B, MGC34595, GPIB
Mouse
IgG1
100 μg
4° C
Primary
2811
Flow Cytometry
MM2/174
APC
GP1BA
Liquid
GP1BA
human CD42b
Purified
RUO
Antibody
Monoclonal
Human
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