CD42b Rabbit anti-Human, Porcine, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-8307	Proteintech Group Inc 128601AP150UL	150 μL

Description

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

Specifications

• Antigen: CD42b
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Pig
• Gene Accession No.: P07359
• Gene ID (Entrez): 100515052, 2811
• Immunogen: CD42b Fusion Protein Ag3893
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: GP1BA

• Concentration: 0.33 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: BSS, CD42b, CD42b alpha, GP1B, GP1BA
• Gene Symbols: GP1BA
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody