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CD42d Mouse Anti-Rat, Brilliant Violet 786, Clone: RPM.4, BD Optibuild™

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 743622

Catalog No. BDB743622


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Description

Description

The RPM.4 monoclonal antibody specifically recognizes CD42d (Platelet glycoprotein V, GPV). CD42d is a 88-kDa type I transmembrane glycoprotein which noncovalently associates with GPIb and GPIX to form a receptor for von Willebrand factor on megakaryocytes and resting platelets. The binding sites for von Willebrand factor and thrombin have been localized to the GPIb chain of the GPI-b-V-IX complex. GPV is cleaved by thrombin to release a 70 kDa soluble fragment, which contains the epitope recognized by mAb RPM.4. Although the rat CD42d protein's structure is similar to that of human CD42d, the RPM.4 antibody does not cross-react with human platelets.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD42d
RPM.4
Brilliant Violet 786
PLGPV, Gp5, platelet glycoprotein V, GPV, Platelet glycoprotein 5
Wistar rat platelets
50 μg
Primary
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Mouse
Affinity Purified
RUO
Mouse
IgG2a κ
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