Invitrogen™ CD43 Monoclonal Antibody (W3/13HLK), FITC

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA517384	Invitrogen™ MA517384	100 μg
PIMA517385	Invitrogen™ MA517385	500 μg

Description

CD43 Monoclonal Antibody for Flow

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

Specifications

• Antigen: CD43
• Concentration: 0.1 mg/mL
• Applications: Flow Cytometry
• Conjugate: FITC
• Host Species: Mouse
• Regulatory Status: RUO
• Formulation: PBS with 4-5mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: P13838
• Gene ID (Entrez): 24796
• Immunogen: Rat thymocyte membrane.
• Product Type: Antibody

• Clone: W3/13HLK
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG1
• Target Species: Rat
• Gene: SPN
• Gene Alias: 3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
• Gene Symbols: SPN
• Primary or Secondary: Primary
• Purification Method: Protein G