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CD43/Sialophorin Antibody (DF-T1), Alexa Fluor™ 594, Novus Biologicals™
SDP

Catalog No. NB005690 Shop All R&D Systems Products
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NB005690 0.1 mL
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Catalog No. NB005690 Supplier Novus Biologicals Supplier No. NBP233140AF594
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Description

Mouse Monoclonal Antibody

CD43/Sialophorin Monoclonal specifically detects CD43/Sialophorin in Human samples. It is validated for Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

Specifications

Antigen CD43/Sialophorin
Applications Western Blot, Flow Cytometry, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone DF-T1
Conjugate Alexa Fluor 594
Dilution Western Blot, Flow Cytometry, ELISA, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias CD43 antigen, CD43), Galactoglycoprotein, GALGP, Leukocyte sialoglycoprotein, Sialophorin, sialophorin (gpL115, leukosialin, CD43)
Gene Symbols SPN
Host Species Mouse
Immunogen Myeloblastic KG1 cells were used as the immunogen for this antibody.
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline B Cell Development and Differentiation Markers, Immunology
Primary or Secondary Primary
Test Specificity It recognizes a cell surface glycoprotein of 95/115/135kDa (depending upon the extent of glycosylation), identified as CD43 [Workshop IV]. Epitope of monoclonal antibody Bra7G is clearly different from that of monoclonal antibody DF-T1, called b as opposed to a for DF-T1. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of the lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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