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CD45.2 Mouse anti-Mouse, Alexa Fluor® 647, Clone: 104, Invitrogen™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A14737

Catalog No. 50-113-7638


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Description

Description

CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Specifications

Specifications

CD45.2
Monoclonal
0.5 mg/mL
PBS with 0.1% sodium azide
P06800
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C, PTPRC
Mouse
IgG2a, kappa
25 μg
4° C
Primary
19264
Flow Cytometry
104
Alexa Fluor® 647
Ptprc
Liquid
Ptprc
B10.S mouse thymocytes and splenocytes.
Purified
RUO
Antibody
Monoclonal
Mouse
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