Invitrogen™ CD45.2 Monoclonal Antibody (104), FITC

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MCD45201

Catalog No. 50-113-8110

Description

CD45.2 Monoclonal Antibody for Flow

CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Specifications

• Antigen: CD45.2
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with <0.1% sodium azide; pH 7.4
• Gene Accession No.: P06800
• Gene Symbols: Ptprc
• Immunogen: B10.S mouse thymocytes and splenocytes.
• Quantity: 500 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Flow Cytometry
• Clone: 104
• Conjugate: FITC
• Gene: Ptprc
• Gene Alias: B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 19264
• Content And Storage: 4°C, store in dark
• Form: Liquid