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CD45 Antibody (2B11 + PD7/26), Alexa Fluor™ 750, Novus Biologicals™
SDP

Catalog No. NP23428A70 Shop All R&D Systems Products
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NP23428A70 0.1 mL
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Catalog No. NP23428A70 Supplier Novus Biologicals Supplier No. NBP234528AF750
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Description

Mouse Monoclonal Antibody

CD45 Monoclonal specifically detects CD45 in Human, Canine samples. It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen CD45
Applications Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 2B11 + PD7/26
Conjugate Alexa Fluor 750
Dilution Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Formulation 50 mM sodium borate with 0.05% sodium azide
Gene Alias B220, CD45 antigen, CD45R, EC 3.1.3.48, L-CA, LY5, protein tyrosine phosphatase, receptor type, C, receptor-type tyrosine-protein phosphatase C, T200 glycoprotein, T200 leukocyte common antigen, T200receptor type, c polypeptide
Gene Symbols PTPRC
Host Species Mouse
Immunogen Isolated neoplastic cells from T cell lymphoma (2B11); and human peripheral blood lymphocytes maintained in T cell growth factor (PD7/26)
Purification Method Protein A or G purified
Quantity 0.1 mL
Primary or Secondary Primary
Gene ID (Entrez) 5788
Test Specificity Recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this monoclonal antibody is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.
Target Species Human, Canine
Content And Storage Store at 4°C in the dark.
Isotype IgG1 κ
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