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CD45 Recombinant Rabbit Monoclonal Antibody (BL-178-12C7), Bethyl Laboratories

Catalog No. 501571277
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50-157-1277 100 μL
50-157-1278 10 μL
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Catalog No. 50-157-1277 Supplier Bethyl Laboratories, Inc Supplier No. A700012
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Description

Rabbit Recombit Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommende

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Specifications

Antigen CD45
Applications Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone BL-178-12C7
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene PTPRC
Gene Accession No. P08575
Gene Alias B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase; receptor type; c polypeptide; receptor-type tyrosine-protein phosphatase C; HCD45
Gene Symbols PTPRC
Host Species Rabbit
Immunogen Between 1254 and 1304
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5788
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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