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CD45R Mouse, anti-Rat, R718, Clone: HIS24, BD OptiBuild™

Catalog No. BDB751974 Shop All BD Biosciences Products
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BDB751974 50 μg
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Catalog No. BDB751974 Supplier BD Biosciences Supplier No. 751974
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Description

Mouse Monoclonal Antibody

The HIS24 antibody reacts with a developmentally regulated form of CD45 found on most B lymphocytes, including developing B cells in the bone marrow and peripheral B cells, but not plasma cells. The level of expression of this CD45R antigen appears to be an indicator of both maturational stages in the B-cell lineage and of functionally distinct B-cell subsets. The HIS24 mAb, in combination with other markers such as TdT and Ig expression, is effective in the identification of B-cell progenitors. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the rat are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45R
Applications Flow Cytometry
Classification Monoclonal
Clone HIS24
Conjugate R718
Host Species Mouse
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Rat
Content And Storage Refrigerate Upon Arrival
Form Liquid
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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