Invitrogen™ CD45RB Monoclonal Antibody (16A), Biotin

Rat Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA517882	Invitrogen™ MA517882	100 μg
PIMA517883	Invitrogen™ MA517883	300 μg

Description

CD45RB Monoclonal Antibody for IHC (F), IHC (P), Flow

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.

Specifications

• Antigen: CD45RB
• Concentration: 0.1 mg/mL
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
• Conjugate: Biotin
• Host Species: Rat
• Regulatory Status: RUO
• Formulation: PBS with 4-5 mg/mL BSA and 0.02% sodium azide
• Gene Accession No.: P06800
• Gene ID (Entrez): 19264
• Immunogen: TH2 cell clones, final boost with TH2 clone D10 Fusion Partner: Ag8.653.
• Product Type: Antibody

• Clone: 16A
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Classification: Monoclonal
• Form: Liquid
• Isotype: IgG2a
• Target Species: Mouse
• Gene: Ptprc
• Gene Alias: B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
• Gene Symbols: Ptprc
• Primary or Secondary: Primary
• Purification Method: Protein G