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Invitrogen™ CD45RB Monoclonal Antibody (CC76), FITC
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Catalog No. PIMA528399
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100 μg
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Catalog No. Quantity
PIMA528399 100 μg
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Catalog No. PIMA528399 Supplier Invitrogen™ Supplier No. MA528399
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Description

Mouse Monoclonal Antibody

Mouse anti Bovine CD45RB, clone CC76, recognizes the RB isoform of the bovine leucocyte common antigen expressed on subpopulations of CD4+ and CD8+ T cells.

CD45RB is a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RB is expressed in microglia and inflammatory cells. In addition to involvement in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is involved in DNA fragmentation during apoptosis. CD45 is expressed on cells of the human hematopoietic lineage with the exception of mature red cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD45RB
Applications Flow Cytometry
Classification Monoclonal
Clone CC76
Concentration 100 μg/mL
Conjugate FITC
Formulation PBS with 1% BSA and 0.09% sodium azide
Gene Ptprc
Gene Accession No. 0
Gene Alias B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; Leukocyte common antigen; loc; LY5; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
Gene Symbols Ptprc
Host Species Mouse
Immunogen Bovine Thymocytes.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 407152
Target Species Bovine
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Product Type Antibody
Form Liquid
Isotype IgG1
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