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CD45RB Mouse anti-Human, Clone: DF-B1, Abnova™

Mouse monoclonal antibody raised against native human CD45RB.

Manufacturer:  Abnova Corporation MAB13408

Catalog No. 89-933-832


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Description

Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]

Specifications

Specifications

CD45RB
DF-B1
Mouse monoclonal antibody raised against native human CD45RB.
In 10mM PBS.
B220/CD45/CD45R/GP180/LCA/LY5/T200
Mouse
IgG3, kappa
100 ug
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
PTPRC
Extract from Alexander's hepatoma cell line L428.
Protein A/G purification
RUO
Primary
5788
SDS
Documents
Product Certifications
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