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CD45RC Mouse, anti-Mouse, R718, Clone: DNL-1.9, BD OptiBuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 752037

Catalog No. BDB752037


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Description

Description

The DNL-1.9 antibody monoclonal antibody specifically recognizes an exon C-dependent epitope of CD45 protein which is found at high density on B cells, and at low density on peripheral T cytotoxic/suppressor cells, a subset of peripheral T helper cells, and a very small subset of thymocytes. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOHterminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.

Specifications

Specifications

CD45RC
DNL-1.9
Liquid
50 μg
Refrigerate Upon Arrival
Monoclonal
Flow Cytometry
R718
Mouse
RUO
Primary
Mouse
SDS
Documents
Product Certifications
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