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CD45RO Mouse anti-Human, Clone: UCHL-1, Bethyl Laboratories
Mouse Monoclonal Antibody
Supplier: Bethyl Laboratories, Inc A500020AT
Description
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.Specifications
| CD45RO | |
| Monoclonal | |
| Unconjugated | |
| PTPRC | |
| B220, CD45, CD45R, GP180, LCA, LY5, T200 | |
| Mouse | |
| Protein G | |
| RUO | |
| 5788 | |
| 4° C | |
| Liquid |
| Immunocytochemistry, Immunohistochemistry, Western Blot | |
| UCHL-1 | |
| PBS with 0.09% sodium azide | |
| P08575 | |
| PTPRC | |
| Cultured T-cells from an IL-2-dependent T-cell line (CA1) | |
| 10 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2a |
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