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CD45RO Mouse anti-Human, Clone: UCHL-1, Bethyl Laboratories

Catalog No. 501571250
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50-157-1250 10 μL
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Catalog No. 50-157-1250 Supplier Bethyl Laboratories, Inc Supplier No. A500020AT
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Description

Mouse Monoclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

Specifications

Antigen CD45RO
Applications Immunocytochemistry, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone UCHL-1
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene PTPRC
Gene Accession No. P08575
Gene Alias B220, CD45, CD45R, GP180, LCA, LY5, T200
Gene Symbols PTPRC
Host Species Mouse
Immunogen Cultured T-cells from an IL-2-dependent T-cell line (CA1)
Purification Method Protein G
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5788
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG2a
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