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Invitrogen™ CD45RO Monoclonal Antibody (IL-A116), PE
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Catalog No. PIMA528402
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100 Tests
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PIMA528402 100 Tests
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Catalog No. PIMA528402 Supplier Invitrogen™ Supplier No. MA528402
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Description

Mouse Monoclonal Antibody

Mouse anti Bovine CD45RO, clone IL-A116 recognizes the bovine homologue of the human CD45RO cell surface antigen. Reconstitute by adding 1 mL distilled water.

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
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Specifications

Antigen CD45RO
Applications Flow Cytometry
Classification Monoclonal
Clone IL-A116
Concentration Conc. Not Determined
Conjugate PE
Formulation PBS with 1% BSA, 5% sucrose and 0.09% sodium azide
Gene PTPRC
Gene Accession No. 0
Gene Alias B220; Cd45; CD45 antigen; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen
Gene Symbols PTPRC
Host Species Mouse
Immunogen Bovine peripheral blood mononuclear cells.
Purification Method Protein A
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 407152
Target Species Bovine
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Lyophilized
Isotype IgG3
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