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CD45RO Mouse anti-Human, Clone: UCH-L1, lyophilized, TrueMAB™
SDP

Catalog No. 501668155
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100 μg
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Catalog No. Quantity
50-166-8155 100 μg
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Catalog No. 50-166-8155 Supplier OriGene Supplier No. CF807197
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Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

Specifications

Antigen CD45RO
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone UCH-L1
Conjugate Unconjugated
Formulation PBS with 8% trehalose and no preservative; pH 7.3
Gene PTPRC
Gene Accession No. P08575
Gene Alias B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Gene Symbols PTPRC
Host Species Mouse
Immunogen IL-2-dependent T-cell line (CA1).
Purification Method Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5788
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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