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CD46 Antibody (MCP/931), Novus Biologicals™
SDP

Catalog No. p-5539561 Shop All R&D Systems Products
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NBP24467200 0.02 mg
NBP24467201 0.1 mg
NBP24467202 0.2 mg
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Catalog No. NBP24467200 Supplier Novus Biologicals Supplier No. NBP2446720.02MG
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Description

Mouse Monoclonal Antibody

Ensure accurate, reproducible results in Flow Cytometry, Immunofluorescence

CD46 Monoclonal specifically detects CD46 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunofluorescence.

Specifications

Antigen CD46
Applications Flow Cytometry, Immunofluorescence
Classification Monoclonal
Clone 197-2B1
Concentration 0.2 mg/mL
Conjugate Unconjugated
Dilution Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence 0.5 - 1.0 ug/ml
Formulation 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Alias AHUS2, CD46 antigen, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen), MIC10, TLXcomplement regulatory protein, trophoblast leucocyte common antigen, Trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen
Gene Symbols CD46
Host Species Mouse
Immunogen Stimulated human leukocytes
Purification Method Protein A or G purified
Quantity 0.02 mg
Regulatory Status RUO
Research Discipline Cancer, Cell Biology, Cellular Markers, Immunology
Primary or Secondary Primary
Gene ID (Entrez) 4179
Test Specificity Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria. This MAb can be applied to test complement activation in pseudo-allergic reactions to acetylsalicylic acid and to test for measles virus infection of cells.
Target Species Human
Content And Storage Store at 4C.
Form Purified
Isotype IgG2a κ
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For Research Use Only

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