CD46 Mouse anti-Human, Brilliant Violet 421, Clone: E4.3, BD Optibuild™

Catalog No.	Quantity
BDB743776	50 μg

Catalog No. BDB743776 Supplier BD Biosciences Supplier No. 743776

Description

Mouse Monoclonal Antibody

The E4.3 monoclonal antibody specifically binds to CD46. CD46 is also known as membrane cofactor protein (MCP). CD46 is a type I membrane glycoprotein composed of two non-disulfide linkedα(66 kDa) andβ(56 kDa) chains expressed on lymphocytes, monocytes and granulocytes. It is not expressed on erythrocytes or platelets. There are four isoforms of the dimer which function as complement regulatory factors. CD46 promotes the enzymatic degradation of activated C3b and/or C4b deposited on host cells. It also serves as the measles virus receptor.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.

Specifications

• Antigen: CD46
• Classification: Monoclonal
• Clone: E4.3
• Concentration: 0.2mg/mL
• Conjugate: Brilliant Violet 421
• Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
• Gene Alias: AHUS2, Membrane cofactor protein, MCP, MIC10, TLX, TRA2.10
• Host Species: Mouse
• Purification Method: Affinity Purified
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
• Isotype: IgG2a κ

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov