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CD49a Mouse anti-Human, Brilliant Violet 510, Clone: SR84, BD Optibuild™

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 742358

Catalog No. BDB742358


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Description

Description

The SR84 monoclonal antibody specifically recognizes CD49a (CD49 antigen-like family member A). CD49a is a ñ200 kDa type I transmembrane molecule that is encoded by ITGA1 ( /Integrin subunit alpha 1). CD49a is also known as very late antigen 1αsubunit (VLA-1) of the integrin family of cell adhesion molecules. CD49a associates with the integrinβ1 subunit (CD29) to form theα1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. It is expressed on activated T cells, monocytes, neuronal cells and smooth muscle cells. CD49a has been reported to play a role in cell attachment during the development of both the central and peripheral nervous systems.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
Specifications

Specifications

CD49a
0.2mg/mL
Aqueous buffered solution containing ≤0.09% sodium azide.
Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
P-Selectin IgG1 Fusion
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon BV510 under optimal conditions that minimize unconjugated dye and antibody.
RUO
Primary
Human
SR84
Brilliant Violet 510
Affinity Purified
Murine
Mouse IgG1, κ
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
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