CD49a Mouse anti-Human, BUV395, Clone: SR84, BD Optibuild
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 742363
The SR84 monoclonal antibody specifically recognizes CD49a (CD49 antigen-like family member A). CD49a is a ñ200 kDa type I transmembrane molecule that is encoded by ITGA1 ( /Integrin subunit alpha 1). CD49a is also known as very late antigen 1αsubunit (VLA-1) of the integrin family of cell adhesion molecules. CD49a associates with the integrinβ1 subunit (CD29) to form theα1/β1 heterodimer (CD49a/CD29), and serves as receptor for collagen and laminin-1. It is expressed on activated T cells, monocytes, neuronal cells and smooth muscle cells. CD49a has been reported to play a role in cell attachment during the development of both the central and peripheral nervous systems.The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry. With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter. BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences. With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter. This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1|
|P-Selectin IgG1 Fusion|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon BUV395 under optimal conditions that minimize unconjugated dye and antibody.|
|Brilliant Ultraviolet 395|
|Mouse IgG1, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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